The perineum in humans is the space between the anus and scrotum in the male, or between the anus and the vulva in the female. The perineum is the region of the body between the pubic symphysis (pubic arch) and the coccyx (tail bone), including the perineal body and surrounding structures. There is some variability in how the boundaries are defined. The perineal raphe is visible and pronounced to varying degrees. The perineum is an erogenous zone.

The word entered English from late Latin via Greek περίναιος ~ περίνεος perinaios, perineos, itself from περίνεος, περίνεοι 'male genitals' and earlier περίς perís 'penis' through influence from πηρίς pērís 'scrotum'. The term was originally understood as a purely male body-part with the perineal raphe seen as a continuation of the scrotal septum since masculinization causes the development of a large anogenital distance in men, in comparison to the corresponding lack of distance in women. As a result of folk etymologies (such as ἰνάω ináō, "to carry off by evacuations"), it is contemporaneously extended to both sexes.